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Thursday 14 March 2019 at 4:00 pm! (Dr. Thomas E. Massey)

Published Thu Mar 7th 2019

a QCRI Frontiers of Cancer Research  presentation!

Thursday 14 March/19 at 4:00 pm.

"Perturbation of DNA Repair in Chemical Carcinogenesis"

Thomas E. Massey, PhD. Professor, DBMS, Queen's University


The ability of carcinogenic chemicals to damage DNA and cause mutations is well established as critical for initiation of chemical carcinogenesis. We have found that treatment of mice with a tumourigenic dose of certain carcinogens also alters DNA repair activity, and that inter-organ differences in effects on DNA repair correlate with susceptibility to the carcinogens. Issues to be resolved include: the mechanistic basis of organ-specific effects on DNA repair; the relevance of DNA repair perturbation in different carcinogen exposure paradigms; and the feasibility of upregulating DNA repair as a chemopreventive strategy.

Everyone is welcome!

Host: Dr. Peter Greer (greerp@queensu.ca)