Selected Publications

Representative Publications (mostly last 7 years) (selected from 228 total)

Review Articles (Invited)

MRP4 Studies

  • Md. T. Hoque, G. Conseil and S.P.C. Cole. Involvement of NHERF1 in apical membrane localization of MRP4 in polarized kidney cells.  Biochem. Biophys. Res. Commun. 379: 60-64 (2009).
  • Md. T. Hoque and S.P.C. Cole. Downregulation of NHERF1 increases expression and function of multidrug resistance protein 4 (MRP4). Cancer Res. 68: 4802-4809 (2008).
  • J. Park, J-O. Kwak, B. Riederer, U. Seidler, S.P.C. Cole, H.J. Lee and M.G. Lee. Na+/H+ exchanger regulatory factor 3 is critical for multidrug resistance protein 4-mediated drug efflux in the kidney. J. Am. Soc. Nephrol. 25: 727-736 (2014). [Highlighted in Nat. Rev. Nephrol. 10: 183 (2014)].
  • L. Cheung, C.L. Flemming, F. Watt, N. Masada, D.M. Yu, T. Huynh, G. Conseil, A. Tivnan, A. Polinsky, A.V. Gudkov, M.A. Munoz, A. Vishvanath, D.M. Cooper, M.J. Henderson, S.P.C. Cole, J.I. Fletcher, M. Haber and M.D. Norris. High-throughput screening identifies Ceefourin-1 and Ceefourin-2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4). Biochem. Pharmacol. 91: 97-108 (2014).
  • D. Jin, T.T. Ni, J. Sun, H. Wan, J.D. Amack, G. Yu, J. Fleming, C. Chiang, W. Li, A. Papierniak, S. Cheepala, G. Conseil, S.P.C. Cole, B. Zhou, I.A. Drummond, J.D. Schuetz, J. Malicki and T.P. Zhong. Prostaglandin signaling regulates ciliogenesis by modulating intraflagellar transport. Nat. Cell. Biol. 16: 841-851 (2014). [Highlighted in News & Views, P. Barbry, L.E. Zaragosi. An ABC of ciliogenesis. Nat. Cell Biol. 16: 826-827 (2014)].

MRP1 Studies - Pharmacogenetics

  • G. Conseil and S.P.C. Cole. Two polymorphic variants of ABCC1 selectively alter drug resistance and inhibitor sensitivity of the multidrug and organic anion transporter MRP1. Drug Metab. Dispos. 41: 2187-2196 (2013).
  • I.J. Létourneau, R.G. Deeley and S.P.C. Cole. Functional characterization of non-synonymous single nucleotide polymorphisms in the gene encoding human multidrug resistance protein 1 (MRP1/ABCC1). Pharmacogenet. Genomics 15: 647-657 (2005).
  • S. Conrad, H-M. Kauffmann, K-i. Ito, E.M. Leslie, R.G. Deeley, D. Schrenk and S.P.C. Cole. A naturally occurring mutation in MRP1 results in a selective decrease in organic anion transport and in increased doxorubicin resistance. Pharmacogenetics 12: 321-330 (2002).
  • S. Conrad, H-M. Kauffmann, K-i. Ito, R. Deeley, S.P.C. Cole and D. Schrenk. Identification of human multidrug resistance protein 1 (MRP1) mutations and characterization of a G671V substitution. J. Hum. Genet. 46: 656-663 (2001).

MRP1 Studies - Structure and Function

  • S.H. Iram and S.P.C. Cole. Differential functional rescue of Lys513 and Lys516 processing mutants of MRP1 (ABCC1) by chemical chaperones reveals different domain-domain interactions of the transporter. Biochim. Biophys. Acta 1838: 756-765 (2014).
  • S.H. Iram and S.P.C. Cole. Mutation of Glu521 or Glu535 in cytoplasmic loop 5 cause differential misfolding in multiple domains of the multidrug and organic anion transporter MRP1 (ABCC1). J. Biol. Chem. 287: 7543-7555 (2012).
  • S.H. Iram and S.P.C. Cole.  Expression and function of human MRP1 (ABCC1) is dependent on amino acids in cytoplasmic loop 5 and its interface with nucleotide binding domain 2. J. Biol. Chem. 286: 7202-7213 (2011).
  • K. Maeno, A. Nakajima, G. Conseil, A. Rothnie, R.G. Deeley and S.P.C. Cole. Molecular basis for reduced estrone sulfate transport and altered modulator sensitivity of TM6 and TM17 mutants of MRP1 (ABCC1). Drug Metab. Dispos. 37: 1411-1420 (2009).
  • Rothnie, G. Conseil, A.Y.T. Lau, R.G. Deeley and S.P.C. Cole. Mechanistic differences between GSH transport by MRP1 (ABCC1) and GSH modulation of MRP1-mediated transport. Mol. Pharmacol. 74: 1630-1640 (2008).
  • P. Wu, C.J. Oleschuk, Q. Mao, B.O. Keller, R.G. Deeley and S.P.C. Cole. Analysis of human multidrug resistance protein 1 (ABCC1) by matrix-assisted laser desorption ionization/time of flight mass spectrometry: toward identification of leukotriene C4 binding sites. Mol. Pharmacol. 68: 1455-1465 (2005).
  • K. Koike, G. Conseil, E.M. Leslie, R.G. Deeley and S.P.C. Cole. Identification of proline residues in the core cytoplasmic and transmembrane regions of multidrug resistance protein 1 (MRP1/ABCC1) important for transport function, substrate specificity, and nucleotide interactions. J. Biol. Chem. 279: 12325-12336 (2004).
  • E.M. Leslie, R.G. Deeley and S.P.C. Cole. Bioflavonoid stimulation of glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1). Drug Metab. Dispos. 31: 11-15 (2003).
  • K. Koike, C.J. Oleschuk, A. Haimeur, S.L. Olsen, R.G. Deeley and S.P.C. Cole. Multiple membrane associated tryptophan residues contribute to the transport activity and substrate specificity of the human multidrug resistance protein, MRP1. J. Biol. Chem. 277: 49495-49503 (2002).
  • K. Ito, C.J. Oleschuk, C. Westlake, M.Z. Vasa, R.G. Deeley and S.P.C. Cole. Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity. J. Biol. Chem. 276: 38108-38114 (2001).
  • E.M. Leslie, K. Ito, P. Upadhyaya, S.S. Hecht, R.G. Deeley and S.P.C. Cole. Transport of the ß-O-glucuronide conjugate of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the multidrug resistance protein 1 (MRP1/ABCC1): Requirement for glutathione or a non-sulfur-containing analog. J. Biol. Chem. 276: 27846-27854 (2001).
  • S.P.C. Cole, G. Bhardwaj, J.H. Gerlach, J.E. Mackie, C.E. Grant, K.C. Almquist, A.J. Stewart, E.U. Kurz, A.M.V. Duncan, and R.G. Deeley. Overexpression of a transporter gene in a multidrug resistant human lung cancer cell line. Science 258: 1650-1654 (1992). [2,441 citations-07/2013]