2004

  1. J.D. Campbell, K. Koike, C. Moreau, M.S.P. Sansom, R.G. Deeley and S.P.C. Cole. Molecular modeling correctly predicts the functional importance of Phe594 in transmembrane helix 11 of the multidrug resistance protein, MRP1 (ABCC1). J. Biol. Chem. 279: 463-368 (2004).
  2. K. Koike, G. Conseil, E.M. Leslie, R.G. Deeley and S.P.C. Cole. Identification of proline residues in the core cytoplasmic and transmembrane regions of multidrug resistance protein 1 (MRP1/ABCC1) important for transport function, substrate specificity, and nucleotide interactions. J. Biol. Chem. 279: 12325-12336 (2004).
  3. K. Koike, R.G. Deeley and S.P.C. Cole. Mapping of the MRPm5 epitope to the cytosolic region between transmembrane helices 13 and 14 in the drug and organic tranpsorter, MRP1 (ABCC1). Biochem. Biophys. Res. Commun. 315: 719-725 (2004).
  4. A. Haimeur, G. Conseil, R.G. Deeley and S.P.C. Cole. The MRP-related and BCRP/ABCG2 multidrug resistance proteins: biology, substrate specificity and regulation. Curr. Drug Metab. 5: 21-53 (2004) (invited review). (One of Canada's Top 10 Hot Papers, April 2004-February 2006. http://www.in-cites.com/countries/Canada-top10papers2006).
  5. A. Haimeur, G. Conseil, R.G. Deeley and S.P.C. Cole. Mutations of charged amino acids in or proximal to the transmembrane helices of the second membrane spanning domain differentially affect the substrate specificity and transport activity of the multidrug resistance protein, MRP1 (ABCC1). Mol. Pharmacol. 65: 1375-1385 (2004).
  6. Q. Mao, G. Conseil, A. Gupta, S.P.C. Cole and J.N. Unadkat. Functional expression of the human breast cancer resistance protein (BCRP/ABCG2) in Pichia pastoris. Biochem. Biophys. Res. Commun. 320: 730-737 (2004).
  7. D-W. Zhang, K. Nunoya, M. Vasa, H-M. Gu, A. Theis, S.P.C. Cole and R.G. Deeley. Transmembrane helix 11 of multidrug resistance protein 1 (MRP1/ABCC1): Identification of polar amino acids important for substrate specificity and binding of ATP at nucleotide binding domain 1. Biochemistry 43: 9413-9425 (2004).
  8. D. Situ, A. Haimeur, G. Conseil, K.E. Sparks, D. Zhang, R.G. Deeley and S.P.C. Cole. Mutational analysis of ionizable residues proximal to the cytoplasmic interface of membrane spanning domain 3 of the multidrug resistance protein, MRP1 (ABCC1). J. Biol. Chem. 279: 38871-38880 (2004).
  9. P.W. Causey, M.C. Baird and S.P.C. Cole. Synthesis, characterization and assessment of cytotoxic properties of a series of titanocene dichloride derivatives. Organometallics 23: 4486-4494 (2004).
  10. C.J. Westlake, L. Payen, M. Gao, S.P.C. Cole and R.G. Deeley. Identification and characterization of functionally important elements in the multidrug resistance protein 1 COOH-terminal region. J. Biol. Chem. 279: 53571-53583 (2004).