Publications

Publications:
2016

Rao, S.-.S., Mu, Q., Zeng, Y., Cai, P.-.C., Yang, J., Xia, Y., Zhang, Q., Song, L.-.J., Zhou, L.-.L., Li, F.-.Z., Lin, Y.-.L., Fang, J., Greer, P.A., Shi, H.-.Z., Ma, W.-.L., Su, Y., and Ye, H. 2016. Calpain-activated mTORC2/Akt pathway mediates airway smooth muscle remodeling in asthma. Clinical & Experimental Allergy (In press)

 

Li, S., Zhang, Zhang, L., Xiong, S, Greer, P.A., Fan, G.-G., and Peng, T.  2016. Disruption of calpain reduces lipotoxcity-induced cardiac injury by preventing endoplasmic reticulum stress. BBA – Molecular Basis of Disease 1862:2023-33

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=27523632

 

Fan, G., Zhang, S., Gao, Y., Greer, P.A. and Tonks, N.K. 2016. HGF-independent regulation of MET and GAB1 by non-receptor tyrosine kinase FER potentiates metastasis in ovarian cancer. Genes and Development 30: 1542-57

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=27401557

 

Yang, J., Xiang, F., Cai, P.-C., Lu, Y.-Z., Xu, X.-X., Yu, F., Li, F.-Z., Greer, P.A., Shi, H.-Z., Zhou, Q., Xin, J.-B., Ye, H., Su, Y., and Ma, W.-L.  2016. Activation of calpain by renin-angiotensin system in pleural mesothelial cells mediates tuberculous pleural fibrosis. American Journal of Physiology Lung Cellular and Molecular Physiology 311:L145

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=27261452

 

Alvau, A., Battistone, M.A., Gervasi, M.G., Salicioni, A.M., Navarrete, F.A., Sanchez, C., De la Vega-Beltran, J.L., Greer, P.A., Darszon, A., Cuasnicu, P., Visconti, P.E. 2016. The tyrosine kinase Fer is responsible for the capacitation-associated increase in tyrosine phosphorylation. Development 143: 2325-33

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=27226326

 

Grieve, S., Gao, Y., Hu, J., Hall, C., and Greer, P.A. 2016. Calpain genetic disruption and HSP90 inhibition combine to attenuate mammary tumorigenesis. Molecular & Cellular Biology 36:2078-88

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=27215381

 

2015

Ni, R., Zheng, D., Xiong, S., Hill, D., Sun, T., Gardnier, R., Fan, G.-C., Lu, Y., Abel, D., Greer, P.A., Peng, T. 2015. Mitochondrial calpain-1 disrupts ATP synthase and induces superoxide generation in type-1 diabetic hearts: a novel mechanism contributing to diabetic cardiomyopathy. Diabetes 65:255-68

http://diabetes.diabetesjournals.org/content/early/2015/10/08/db15-0963.long

 

Ni, R, Zheng, D., Wang, Q., Yu, Y., Chen, R., Sun, T., Wang, W., Zhang, H., Fan, G.-C., Greer, P.A. Gardiner, R., and Peng, T. 2015. Deletion of capn4 protects the heart against endotoxemic injury by preventing ATP synthase disruption and inhibiting mitochondrial superoxide generation.  Circulation: Heart Failure 8:988-996.

http://www.ncbi.nlm.nih.gov/pubmed/26246018?dopt=Citation

 

Hoskin, V., Szeto, V., Ghaffari, A., Greer, P.A., Côté, G.P., and Elliott, B.E., 2015. Ezrin regulates focal adhesion and invadopodia dynamics by altering calpain activity to promote breast cancer cell invasion.  Molecular Biology of the Cell. 26:3464-79

http://www.ncbi.nlm.nih.gov/pubmed/26246600?dopt=Citation

 

Zhang, S., Kim, H., Mullins, G.S., LeBrun, D., Elliott, B.E., and Greer, P. A. 2015. Interleukin-4 Expressed By Neoplastic Cells Provokes an Anti-Metastatic Myeloid Immune Response. Journal of Clinical & Cellular Immunology 6:329-47

http://www.omicsonline.org/open-access/interleukin4-expressed-by-neoplastic-cells-provokes-an-antimetastaticmyeloid-immune-response-2155-9899-1000329.pdf

 

Li, F.-Z., Cai, P.-C., Song, L.-J., Zhou, L.-L., Zhang, Q., Xiang, F., Zhang, J.-C., Rao, S.-S., Xia, Y., Xiang, F., Xin, J.-B., Greer, P.A., Shi, H.-Z., Su, Y., Ma, W.-L., Ye, H. 2015. Crosstalk between calpain activation and TGF-β1 augments collagen-I synthesis in pulmonary fibrosis. BBA-Molecular Basis of Disease 1852:1796 http://www.sciencedirect.com/science/article/pii/S092544391500174X

 

Yang, J., Wu, Z., Renier, N., Simon, D.J., Uryu, K., Park D.S., Greer, P.A., Tournier, C., Davis, R.J., and Tessier-Lavigne, M. 2015. Pathological axonal death through a MAPK cascade that triggers local energy deficit.  Cell 160:161-176

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=25594179

 

2014

Lu, S., Kanekura, K., Hara, T., Mahadevan, J., Spears, L.D., Oslowski, C.M., Marinez, R., Yamazaki-Inoue, M., Toyoda, M., Neilson, A., Blanner, P.M., Brown, C., Semenkovich, C.F., Marshall, B.A., Hershey, T., Umezawa, A., Greer, P.A., and Urano, F.  2014. A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome.  PNAS 111: E5292-301

http://www.pnas.org/content/early/2014/11/20/1421055111.full.pdf+html

 

Williams, J.L., Greer, P.A., and Squire, J.A. 2014. Recurrent copy number alterations in prostate cancer: an in silico meta-analysis of publicly available genomic data. Cancer Genetics 207:474-488

http://www.sciencedirect.com/science/article/pii/S2210776214001793

 

Sangrar, W. Shi, C., Mullins, G.S., LeBrun, D., Ingalls, B., and Greer, P.A. 2014. Amplified Ras-MAPK signal states correlate with accelerated EGFR internalization, cytostasis and delayed HER2 tumor onset in Fer-deficient model systems. Oncogene 34:4109-17

http://www.ncbi.nlm.nih.gov/pubmed/25347743

 

Redpath, G.M., Woolger, N., Piper, A.K., Lemckert, F.A., Lek, A., Greer, P.A., North, K.N., Cooper, S.T. 2014. Calpain cleavage within dysferlin exon 40a releases a synaptotagmin-like module for membrane repair. Mol. Biol. Cell. 25:3037-3048

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230592/

 

Kumar, V., Everingham, S., Hall, C., Greer, P.A. and Craig, A.W.B. 2014. Calpains promote neutrophil recruitment and bacterial clearance in an acute bacterial peritonitis model. European Journal of Immunology 44:831

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=24375267

 

2013

Elagib, K.E., Rubinstein, J.D., Delehanty, L.L., Ngoh, V., Greer, P.A., Li, S., Lee, J.K., Orkin, S.H., Mihaylov, I.S. and Goldfarb, A.N.  2013 Calpain 2 Activation of P-TEFb Drives Megakaryocyte Morphogenesis and Is Disrupted by Leukemogenic GATA1 Mutation. Developmental Cell 27:607

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=24369834

 

Nagaria, T., Williams, J.L., Leduc, C., Squire, J.A., Greer, P.G, and Sangrar, W. 2013 Flavopiridol synergizes with Sorafenib to induce cytotoxicity and potentiate anti-tumorigenic activity in EGFR/HER-2 and mutant RAS/RAF breast cancer model systems. Neoplasia 15:939-51

http://www.ncbi.nlm.nih.gov/pubmed/23908594

 

Miyata, Y., Kanda, S., Sakai, H., and Greer, P.A. 2013. Feline sarcoma-related protein expression correlates with malignant aggressiveness and poor prognosis in renal cell carcinoma. Cancer Science 104:681

http://www.ncbi.nlm.nih.gov/pubmed/23445469?dopt=Citation

 

Amini, M., Ma, C. Farazifard, R., Zhang, Y.H., Vanderluit, J.,  Zoltewicz, J.S., Hage, F., Savitt, J.M., Lagace, D., Slack, R.S., Beique, J.C., Greer, P.A., Richard Bergeron, R., Park, D.S. 2013.  Conditional disruption of calpain in CNS alters dendrite morphology, impairs LTP, and promotes neuronal survival following injury. J. Neuroscience 33:5773-84

http://www.ncbi.nlm.nih.gov/pubmed/23536090

 

Khajah, M., Andonegui, G., Chan, R., Craig, A.W., Greer, P.A. and McCafferty, D.M. 2013. Fer Kinase Limits Neutrophil Chemotaxis towards End Target Chemoattractants.  J. Immunol. 190:2208-16

http://www.ncbi.nlm.nih.gov/pubmed/23355730?dopt=Citation

 

2012

Ma, J., Wie, M., Wang, Q., Li, J., Wang, H., Liu, W., Liu, W., Lacefield, J.C., Greer, P.A., Karmazyn, M., Fan, G., and Peng, T. 2012. Deficiency of Capn4 inhibits NF-kB signaling/inflammation and reduces remodeling after myocardial infarction. J. Biol. Chem. 287:27480

http://www.ncbi.nlm.nih.gov/pubmed/22753411?dopt=Citation

 

Kwok, E., Everingham, S., Zhang, S., Greer, P.A., Allingham, J.S. and Craig, A.W.B. 2012.

FES kinase promotes mast cell recruitment to mammary tumors via the stem cell factor/KIT receptor signaling axis. Molecular Cancer Research 10:881-91

http://www.ncbi.nlm.nih.gov/pubmed/22589410?dopt=Citation

 

Ho., W.C., Pikor, L, Gao, Y., Elliott, B.E., and Greer, P.A. 2012. Calpain 2 regulates the Akt-FoxO-p27Kip1 signaling pathway in mammary carcinoma. J. Biol. Chem. 287:15458-15465

http://www.ncbi.nlm.nih.gov/pubmed/22427650?dopt=Citation

 

Greer, P.A., Kanda, S., and Smithgall, T.E. 2012. The contrasting oncogenic and tumor suppressor roles of FES.  Frontiers in Bioscience 4:489-501

http://www.ncbi.nlm.nih.gov/pubmed/22202072?dopt=Citation

 

2011

Ma, W., Han, W., Greer, P.A., Tuder, R., Toque, H.F., Wang, K.K.W. Caldwell, R.W. and Su, Y. 2011. Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuated pathologic features of disease. J. Clinical Invest. 121:4548-66

http://www.ncbi.nlm.nih.gov/pubmed/22005303?dopt=Citation

 

Li, Y., Ma, J., Zhu, H., Singh, M., Hill, D., Greer, P.A., Arnold, J. A., Abel, E.D. and Peng, T., 2011. Targeted inhibition of calpain reduces myocardial hypertrophy and fibrosis in mouse models of type-I diabetes. Diabetes 60:2985-94

http://www.ncbi.nlm.nih.gov/pubmed/21911754?dopt=Citation

 

Miyata, Y., Watanabe, S., Matsuo, T., Maruta, S., Hayashi, T., Sakai, H., Xuan, J.W., Greer, P.A. and Kanda, S.  2011. Pathological significance and predictive value for biochemical recurrence of c-Fes expression in prostate cancer. Prostate 72:201-8

http://www.ncbi.nlm.nih.gov/pubmed/21563194?dopt=Citation

 

Zhang, S., Chitu, V., Stanley, R., Elliott, B., and Greer, P.A. 2011. Fes tyrosine kinase expression in the tumor niche correlates with enhanced tumor growth, angiogenesis, circulating tumor cells, metastasis and infiltrating macrophages. Cancer Research 71:1465-1473

http://www.ncbi.nlm.nih.gov/pubmed/21159660?dopt=Citation

 

2010

Wernimont, S.A., Simonson, W.T.N., Greer, P.A., Seroogy, C.M. and Huttenlocher, A. 2010. Calpain 4 is not necessary for LFA-1-mediated function in CD4+ T cells. PLoS ONE 5:10513

http://www.ncbi.nlm.nih.gov/pubmed/20479866?dopt=Citation

 

Kashiwagi, A., Schipani, E., Fein, M., Greer, P.A. and Shimada, M. 2010. Targeted deletion of Capn4 in cells of the chondrocyte lineage impairs chondrocyte proliferation and differentiation. Molecular and Cellular Biology 30:2799-2810 http://www.ncbi.nlm.nih.gov/pubmed/20368361?dopt=Citation

 

2009

Mellgren, R.L., Miyake, K., Kramerova, I., Spencer, M.J., Richard, I., Greer, P.A., and McNeil, P.L.  2009. Calcium-dependent plasma membrane repair requires m- or m-calpain, but not calpain-3, proteasome, or caspases. Biochim. Biophys. Acta 1793:1886-93.

http://www.ncbi.nlm.nih.gov/pubmed/19781581?dopt=Citation

 

Truesdell, P.F., Zirngibl, R.A., Francis, S., Sangrar, W. and Greer, P.A. 2009.  fps/fes knockout mice display a lactation defect and the Fps/Fes tyrosine kinase is a component of E-cadherin-based adherens junctions in breast epithelial cells during lactation.  Experimental Cell Research 315:2929-2940

http://www.ncbi.nlm.nih.gov/pubmed/19732771?dopt=Citation

 

Trümpler, A., Schlott, B., Herrlich, P., Barford, D., Greer, P.A., Böhmer, F.-D. 2009. Calpain-mediated degradation of reversibly oxidized protein-tyrosine phosphatase 1B. FEBS J. 276:5622-5633

http://www.ncbi.nlm.nih.gov/pubmed/19712109?dopt=Citation

 

Wang, Y., Kim, N., Greer, P.A., Dawson, V.L. and Dawson, T.M.  2009. Calpain activation is not required for AIF translocation in PARP-1-dependent cell death (Parthanatos).  J. Neurochemistry 110:687-696

http://www.ncbi.nlm.nih.gov/pubmed/19457082?dopt=Citation

 

Chandramohanadas, R., Davis, P., Darling, C., Beiting, D., Velmourougane, G., Greer, P.A., Roos, D. and Greenbaum, D.C. 2009. Apicomplexan parasites hijack host calpain to egress from host cells.  Science 324:794-797

http://www.ncbi.nlm.nih.gov/pubmed/19342550?dopt=Citation

 

Sangrar, W., Craig, A.W., and Greer, P.A.  2009. Fes and Fer: The F-BAR domain-containing protein-tyrosine kinases.  The Pombe Cdc15 Homology Proteins. Landes Biosciences. Edited by Pontus Aspenstrom

 

2008

Undyala, V.V., Dembo, M., Cembrola, K., Perrin, B.J., Huttenlocher, A., Elce, J.S., Greer, P.A., Wang, Y. L., and Beningo, K.A. 2008. The calpain small subunit regulates cell-substrate mechanical interactions during fibroblast migration.  J. Cell Science 121:3581-3588

http://www.ncbi.nlm.nih.gov/pubmed/18840650?dopt=Citation

 

Shimada, M., Greer, P.A., McMahon, A., Bouxsein, M.L., and Schipani, E. 2008.  In vivo targeted deletion of Capn4 in osteoblasts impairs osteoblast function and bone formation.  J. Biol. Chem. 283:21002-21010

http://www.ncbi.nlm.nih.gov/pubmed/18515801?dopt=Citation

 

2007

Larsen, A.K., Lametsch, R., Elce, J.S., Larsen, J.K., Thomsen, B., Larsen, M.R., Lawson, M.A., Greer, P.A. and Ertbjerg, P., 2007  Genetic disruption of calpain correlates with loss of membrane blebbing and differential expression of RhoGDI-1, cofilin and tropomyosin 1.  Biochemical Journal 411:657-666

http://www.ncbi.nlm.nih.gov/pubmed/18076376?dopt=Citation

 

Shapovalova, Z., Tabunshchyk, K., Püschel, A.W., and Greer, P.A. 2007. The Fer protein tyrosine kinase mediates a neurite collapse response to Semaphorin 3A in dorsal root ganglion neurons. BMC Developmental Biology 7:133

http://www.ncbi.nlm.nih.gov/pubmed/18053124?dopt=Citation

 

Sangrar, W., Gao, Y., Scott, M., Truesdell, P., and Greer, P.A.  2007. Fer-mediated cortactin phosphorylation is associated with efficient fibroblast migration and is dependent on reactive oxygen species generation during integrin-mediated cell adhesion. Molecular and Cellular Biology 27:6140-6152

http://www.ncbi.nlm.nih.gov/pubmed/17606629?dopt=Citation

 

Parsons, S., Mewburn, J.D., Truesdell, P. and Greer, P.A.  2007. The Fps/Fes kinase regulates leukocyte recruitment and extravasation during inflammation. Immunology 122:542-550

http://www.ncbi.nlm.nih.gov/pubmed/17627769?dopt=Citation

 

Moubarak, R.S., Yuste, V. J., Artus, C., Sancho, P., Greer, P.A., Mesissier de Murcia, J., and Susin, S.A. 2007. Sequential activation of PARP-1, calpains and Bax is essential in AIF-mediated programmed necrosis.  Molecular and Cellular Biology 27:4844-62

http://www.ncbi.nlm.nih.gov/pubmed/17470554?dopt=Citation

 

2006

Visram, H., and Greer, P.A., 2006. 17 beta-estradiol and Tamoxifen Stimulate Rapid and Transient ERK Activation in MCF-7 Cells via Distinct Signaling Mechanisms. Cancer Biology and Therapy 5: 1677-82

http://www.ncbi.nlm.nih.gov/pubmed/17106250?dopt=Citation

 

Parsons, S., and Greer, P.A., 2006. The Fps/Fes kinase regulates the inflammatory response to endotoxin through down regulation of TLR4, NF-kB activation, and TNF-a secretion in macrophages.  J. Leukocyte Biology 80:1522-8

http://www.ncbi.nlm.nih.gov/pubmed/16959897?dopt=Citation

 

Tan, Y., Dourdin, N., Wu, C., De Veyra, T., Elce, J.S., and Greer, P.A. 2006. Conditional disruption of ubiquitous calpains in the mouse. Genesis 44: 297-303

http://www.ncbi.nlm.nih.gov/pubmed/16783822?dopt=Citation

 

Tan, Y., Wu, C., De Veyra, T., and Greer, P.A., 2006. Ubiquitous calpains promote both apoptosis and survival signals in response to different death stimuli. J. Bio. Chem. 281: 17689-98

http://www.ncbi.nlm.nih.gov/pubmed/16632474?dopt=Citation

 

Tan, Y., Dourdin, N., Wu, C., De Veyra, T., Elce, J.S. and Greer, P.A. 2006. Ubiquitous Calpains Promote Caspase-12 and Jnk Activation During ER Stress-Induced Apoptosis. J. Biol. Chem. 281:16016-24

http://www.ncbi.nlm.nih.gov/pubmed/16597616?dopt=Citation

 

Dutt, P., Croall, D.E., Arthur, J.S.C., De Veyra, T., Williams, K., Elce, J.S., and Greer, P.A.

 2006. m-Calpain is required for preimplantation embryonic development in mice. BMC Dev. Biol. 6:3

http://www.ncbi.nlm.nih.gov/pubmed/16433929?dopt=Citation

 

2005

El Sayegh, T.Y., Arora, P.D., Laschinger, C.A., Greer, P.A., McCulloch, C.A. and Kapus, A. 2005.  Phosphorylation of N-cadherin-associated cortactin by Fer kinase regulates N-cadherin mobility and intercellular adhesion strength. Molecular Biology of the Cell 16:5514-5527

http://www.ncbi.nlm.nih.gov/pubmed/16176974?dopt=Citation

 

Terry, D., Rees-Milton, K., Smith, P., Pezeshki, P., Woods, C., Greer, P.A., and Anastassiades, T., 2005.  N-acylation of glucosamine modulates chondrocyte growth, proteoglycan synthesis and gene expression.  J. Rheumatology.  32:1775-1786.

http://www.ncbi.nlm.nih.gov/pubmed/16142878?dopt=Citation

 

Sangrar, W., Zirngibl, R.A., Gao, Y., Muller, W.J., Jia, Z., and Greer, P.A.  2005 An identity crisis for fps/fes: Oncogene or tumour-suppressor ? Cancer Research.  65:3518-3522

http://www.ncbi.nlm.nih.gov/pubmed/15867340?dopt=Citation

 

Shimada, M., Mahon, M.J., Greer, P.A. and Serge, G.V. 2005. The receptor for parathyroid hormone and parathyroid hormone-related peptide is hydrolyzed and its signaling properties are altered by directly binding the calpain small subunit. Endocrinology.  146:2336-44

http://www.ncbi.nlm.nih.gov/pubmed/15691895?dopt=Citation

 

Demarchi, F., Bertoli, C., Greer, P.A., and Schneider, C. 2005. Ceramide triggers an NF-kB dependent survival pathway through calpain-mediated degradation of p105.  Cell Death and Differentiation  12:512-522

http://www.ncbi.nlm.nih.gov/pubmed/15933726?dopt=Citation

 

Qi, W., Ebbert, K.V.J., Craig, A.W.B., Greer, P.A., McCafferty, D.-M.  2005. Absence of Fer protein-tyrosine kinase exacerbates endotoxin-induced intestinal epithelial barrier dysfunction in vivo. GUT 54:1091-1097

http://www.ncbi.nlm.nih.gov/pubmed/16009680?dopt=Citation

 

2004

Sangrar, W., Gao, Y., Bates, B., Zirngibl, R.A., and P.A. Greer. 2004. Activated Fps/Fes tyrosine kinase regulates erythroid differentiation and survival. Experimental Hematology 32:935-45

http://www.ncbi.nlm.nih.gov/pubmed/15504549?dopt=Citation

 

Sangrar, W., Senis, Y., Samis, J., Gao, Y., Richardson, M., Lee, D.H., and Greer, P.A. 2004 Hemostatic and hematological abnormalities in gain-of-function fps/fes transgenic mice are associated with the angiogenic phenotype.  Journal of Thrombosis and Haemostasis 2:2009-2019

http://www.ncbi.nlm.nih.gov/pubmed/15550033?dopt=Citation

 

Huynh, H., Bottini, N. Williams, S., Cherepanov, V., Musumeci, L., Saito, K., Bruckner, S., Vachon, E., Wang, X., Kruger, J., Chow, C.-W., Pellecchia, M., Monosov, E., Greer, P.A., Trimble, W., Downey, G.P., and Mustelin, T. 2004. Control of vesicle fusion by a tyrosine phosphatase.  Nature Cell Biology 6:831-839

http://www.ncbi.nlm.nih.gov/pubmed/15322554?dopt=Citation

 

Xu, G., Craig, A., Greer, P., Miller, M., Anastasiades, P., Lilien, J., and Balsamo, J. 2004 Continuous association of cadherin with b-catenin requires the non-receptor tyrosine kinase Fer.  Journal of Cell Science 117:3207-3219

http://www.ncbi.nlm.nih.gov/pubmed/15226396?dopt=Citation

 

Fan, L.,  Di Ciano-Oliveira, C.,  Weed, S.A., Craig, A.W.B., Greer, P.A., Rotstein, O.D., and Kapus, A., 2004. Actin depolymerization-induced tyrosine phosphorylation of cortactin: The role of Fer kinase.  Biochemical Journal 380:581-91

http://www.ncbi.nlm.nih.gov/pubmed/15030313?dopt=Citation

 

Sangrar, W., Mewburn, J., Vincent, S.G., Fisher, J.T., and Greer, P.A. 2004. Vascular defects in gain-of-function fps/fes transgenic mice correlate with PDGF- and VEGF-induced activation of mutant Fps/Fes kinase in endothelial cells. Journal of Thrombosis and Haemostasis 2:820-32

http://www.ncbi.nlm.nih.gov/pubmed/15099290?dopt=Citation

 

Vultur, A., Cao, J., Arulanandam, R., Turkson, J., Jove, R., Greer, P., Craig, A., Elliott, B, Raptis, L.  2004. Cell to cell adhesion modulates Stat3 activity in normal and breast carcinoma cells.  Oncogene 23:2600-2616

http://www.ncbi.nlm.nih.gov/pubmed/15007380?dopt=Citation

 

Haigh, J. J., Ema, M., Haigh, K., Gertsenstein, M., Greer, P.A., Rossant, J., Nagy, A., and Wagner, E.F. 2004. Activated Fps/Fes partially rescues the in vivo developmental potential of Flk1 deficient vascular progenitor cells.  Blood 103 (3): 912-920

http://www.ncbi.nlm.nih.gov/pubmed/14525765?dopt=Citation

 

2003

Sangrar, W., Gao, Y., Zirngibl, R.A., Scott, M.L., and P.A. Greer.  2003. The fps/fes proto-oncogene regulates hematopoietic lineage output.  Experimental Hematology 31:1259-1267

http://www.ncbi.nlm.nih.gov/pubmed/14662333?dopt=Citation

 

Sedarous, M., Keramaris, E., O’Hare, M., Melloni, E., Slack, R.S., Elce, J., Greer, P., and Park, D.S. 2003. Calpains mediate p53 activation and neuronal death evoked by DNA damage. J. Biol. Chem. 278: 26031-38

http://www.ncbi.nlm.nih.gov/pubmed/12721303?dopt=Citation

 

Senis, Y.A., Craig, A.W.B., and Greer, P.A. 2003. Fps/Fes and Fer protein-tyrosine kinases play redundant roles in regulating hematopoiesis.  Experimental Hematology 31: 673-681

http://www.ncbi.nlm.nih.gov/pubmed/12901971?dopt=Citation

 

Senis, Y.A., Sangrar, W., Zirngibl, R., Craig, A.W.B., Lee, D.H. and Greer, P.A.  2003. Fps/Fes and Fer non-receptor protein-tyrosine kinases regulate collagen- and ADP- induced platelet aggregation   J. Thrombosis and Haemostasis 1:1062-1070

http://www.ncbi.nlm.nih.gov/pubmed/12871378?dopt=Citation

 

2002

Postovit, L.-M., Dutt, P., Dourdin, N., Park, M., Greer, P.A., Graham, C.H. and Elce, J.S. 2002. Calpain is required for MMP-2 and u-PA expression in SV40 large T-antigen-immortalized cells. Biochem. Biophys. Res. Comm. 297:294-301

http://www.ncbi.nlm.nih.gov/pubmed/12237117?dopt=Citation

 

Craig, A.W.B. and Greer, P.A. 2002. Fer kinase is required for sustained p38 kinase activation and maximal chemotaxis of activated mast cells Mol. Cell. Biol. 22:(18) 6363-6374

http://www.ncbi.nlm.nih.gov/pubmed/12192036?dopt=Citation

 

Greer, P.A. Closing in on the biological roles of Fps/Fes and Fer protein-tyrosine kinases. 2002. Nature Reviews Molecular Cell Biology 3:278-289

http://www.ncbi.nlm.nih.gov/pubmed/11994747?dopt=Citation

 

McCafferty, D.M., Craig, A.W.B., and Greer, P.A. 2002. Absence of Fer protein-tyrosine kinase exacerbates leukocyte recruitment in response to endotoxin.  J. Immunol. 168:4930-4935

http://www.ncbi.nlm.nih.gov/pubmed/11994443?dopt=Citation

 

Zirngibl, R., Senis, Y., and Greer, P.A. 2002. Enhanced endotoxin-sensitivity in Fps/Fes-null mice with minimal defects in hematopoietic homeostasis. Mol. Cell. Biol. 22:2472-2486

http://www.ncbi.nlm.nih.gov/pubmed/11909942?dopt=Citation

 

Carragher, N.O., Westhoff, M.A., Riley, D., Potter, D.A., Dutt, P., Elce, J.S., Greer, P.A., and Frame. M.C. 2002. v-Src induced modulation of the calpain-calpastatin proteolytic system regulates both morphological transformation and cell cycle progression. Mol. Cell. Biol. 22: 257-269

http://www.ncbi.nlm.nih.gov/pubmed/11739739?dopt=Citation

 

2001

Dourdin, N., Bhatt, A. K., Greer, P. A., Arthur, J. S. C., Elce, J. S., and Huttenlocher, A. 2001.  Reduced cell migration and disruption of the actin cytoskeleton in calpain-deficient embryonic fibroblasts. J. Biol. Chem.276: 48382-48388

http://www.ncbi.nlm.nih.gov/pubmed/11602605?dopt=Citation

 

Keller, P., Payne, J. L., Tremml, G., Greer, P. A., Gaboli, M., Pandolfi, P. P., and Bessler, M 2001. FES-Cre targets PIGA inactivation to hematopoietic stem cells in the bone marrow. J. Exp. Med. 194: (5) 581-589

http://www.ncbi.nlm.nih.gov/pubmed/11535627?dopt=Citation

 

Zirngibl, R., Schulze, D., Mirski, S.E.L, Cole, S.P.C, and Greer, P.A. 2001 Subcellular localization analysis of the closely related Fps/Fes and Fer protein-tyrosine kinases suggests a distinct role for Fps/Fes in vesicular trafficking.  Experimental Cell Research 266:87-94

http://www.ncbi.nlm.nih.gov/pubmed/11339827?dopt=Citation

 

Bovenkamp, D.E. and Greer, P.A. 2001 Degenerate PCR-based cloning method for Eph receptors and analysis of their expression in the developing murine CNS and vasculature. DNA and Cell Biology 20:203-213

http://www.ncbi.nlm.nih.gov/pubmed/11403717?dopt=Citation

 

Craig, A.W.B., Zirngibl, R., Williams, K., Cole, L.A. and Greer, P.A. 2001.  Mice devoid of Fer protein-tyrosine kinase activity are viable and fertile, but display reduced cortactin phosphorylation. Molecular and Cellular Biology 21:603-613

http://www.ncbi.nlm.nih.gov/pubmed/11134346?dopt=Citation

 


Zirngibl, R. and Greer, P. 2001. Analysis of protein kinase subcellular localization by visualization of GFP fusion proteins.  Methods in Molecular Biology 124:195-208

http://www.ncbi.nlm.nih.gov/pubmed/11100477?dopt=Citation

 

2000

Arthur, J.S.C., Elce, J.S., Hegadorn, C., Williams, K. and Greer, P.A.  2000. Disruption of murine calpain small subunit gene, Capn4: Calpain is essential for embryonic development but not for cell growth and division. Molecular and Cellular Biology 20:4474-4481

http://www.ncbi.nlm.nih.gov/pubmed/10825211?dopt=Citation

 

1999

Senis, Y., Zirngibl, R., McVeigh, J., Haman, A., Hoang, T., and Greer, P.A. 1999.  Targeted disruption of the murine fps/fes proto-oncogene reveals that Fps/Fes kinase activity is dispensable for hematopoiesis. Molecular and Cellular Biology 19:7436-7446

http://www.ncbi.nlm.nih.gov/pubmed/10523632?dopt=Citation

 

Craig, A., Zirngibl, R. and Greer, P.  1999.  Disruption of coiled-coil domains in Fer protein kinase abolishes trimerization but not kinase activation. J. Biological Chemistry 274(28):19934-19942

http://www.ncbi.nlm.nih.gov/pubmed/10391941?dopt=Citation

 

Cole, L.A., Zirngibl, R., Craig, A., Jia, Z. and Greer, P.  1999.  Mutation of a highly conserved aspartate residue in subdomain IX abolishes Fer protein-tyrosine kinase activity.  Protein Eng. 12(2):155-162

http://www.ncbi.nlm.nih.gov/pubmed/10195287?dopt=Citation

 

1993-1998

Arthur, J.S.C., Greer, P. and Elce, J. S.  1998.  Structure of the mouse calpain small subunit gene.  Biochim. Biophys. Acta 1388:247-252

http://www.ncbi.nlm.nih.gov/pubmed/9774740?dopt=Citation

 

Mirski, S.E.L., Gerlach, J.H., Cummings, H.J., Zirngibl, R., Greer, P. and Cole, S.P.C. 1997.   Bipartite nuclear localization signals in the C terminus of human topoisomerase IIa . Exp. Cell Res. 237:452-455

http://www.ncbi.nlm.nih.gov/pubmed/9434641?dopt=Citation

 

Bovenkamp, D.E. and Greer, P.  1997.  A novel Eph-family receptor tyrosine kinase is widely expressed in the developing zebrafish nervous system. Dev. Dynam.  209:166-181

http://www.ncbi.nlm.nih.gov/pubmed/9186052?dopt=Citation

 

Haigh, J.,  McVeigh, J. and Greer, P.  1996.  The Fps/Fes tyrosine kinase is expressed in myeloid, vascular endothelial, epithelial and neuronal cells, and is localized in the trans golgi network.  Cell Growth and Diff. 7:931-944

http://www.ncbi.nlm.nih.gov/pubmed/8809411?dopt=Citation

 

Izuhara, K., Feldman, R.A., Greer, P. and Harada, N. 1996. Interleukin-4 induces association of the c-fes proto-oncogene product with phosphatidylinositol-3 kinase.  Blood 88:3910-3918

http://www.ncbi.nlm.nih.gov/pubmed/8916957?dopt=Citation

 

Wang, S.-J., Greer, P. and Auerbach, R.  1996.  Isolation and propagation of yolk sac-derived endothelial cells from a hypervascular transgenic mouse expressing a gain-of-function fps/fes proto-oncogene. In Vitro Cell. & Dev. Biol.  32:292-299

http://www.ncbi.nlm.nih.gov/pubmed/8792159?dopt=Citation

 

Linnekin, D., Mou, S.M., Greer, P., Longo, D.L. and Ferris, D.K.  1995.  Phosphorylation of a Fes-related protein in response to granulocyte-macrophage colony stimulating factor.   J. Biol. Chem. 270: 4950-4954

http://www.ncbi.nlm.nih.gov/pubmed/7876270?dopt=Citation

 

Yang, J. Z., Greer, P., Van Vugt, D.A. and Reid, R.L.  1995. Treatment with 5-aminolevulinic acid and photoactivating light causes destruction of early stage mouse embryos.  Fert. Steril. 63:1088-1093

http://www.ncbi.nlm.nih.gov/pubmed/7720923?dopt=Citation

 

Greer, P., Haigh, J., Mbamalu, G., Khoo, W., Bernstein, A. and Pawson, T.  1994. The Fps/Fes protein-tyrosine kinase promotes angiogenesis in transgenic mice. Mol. Cell. Biol. 14:6755-6763

http://www.ncbi.nlm.nih.gov/pubmed/7523858?dopt=Citation

 

Izuhara, K., Feldman, R.A., Greer, P. and Harada, N. 1994. Interaction of the c-fes proto-oncogene product with the interleukine-4 receptor.  J. Biol. Chem. 269: 18623-18629

http://www.ncbi.nlm.nih.gov/pubmed/7518439?dopt=Citation

 

Chen, L., Zhang, L-J., Greer, P. and Moran, M.F. 1993. A murine CDC25/Ras-GRF-related protein implicated in ras regulation.  Dev. Genet. 14: 339-346

http://www.ncbi.nlm.nih.gov/pubmed/8293576?dopt=Citation

 

Zhang, L., Lemarchandel, V., Romeo, P-H., Ben-David., Y., Greer, P. and Bernstein, A.  1993.  The Fli-1 proto-oncogene, involved in erythroleukemia and Ewing's sarcoma, encodes a transcriptional activator with DNA-binding specificities distinct from other Ets family members.  Oncogene 8:1621-30

http://www.ncbi.nlm.nih.gov/pubmed/8502483?dopt=Citation

 

1988-1991

Lhotak, V., Greer, P., Letwin, K. and Pawson, T.  1991.  Characterization of ELK, a brain-specific receptor tyrosine kinase. Mol. Cell. Biol. 11:2496-2502

http://www.ncbi.nlm.nih.gov/pubmed/2017163?dopt=Citation

 

Greer, P., Maltby, V., Rossant, J., Bernstein, A. and Pawson, T.  1990.  Myeloid expression of the human c-fps/fes proto-oncogene in transgenic mice.  Mol. Cell. Biol. 10:2521-2527

http://www.ncbi.nlm.nih.gov/pubmed/2188092?dopt=Citation

 

Yee, S-P., Mock, D., Greer, P., Maltby, V., Rossant, J., Bernstein, A. and Pawson, T. 1989.  Lymphoid and mesenchymal tumors in transgenic mice expressing the v-fps protein-tyrosine kinase. Mol. Cell. Biol. 9:5491-5499

http://www.ncbi.nlm.nih.gov/pubmed/2555699?dopt=Citation

 

Greer, P., Meckling-Hansen, K. and Pawson, T.  1988.  The human c-fps/fes gene product expressed ectopically in rat fibroblasts is non-transforming and has restrained protein-tyrosine kinase activity.  Mol. Cell. Biol. 8:578-587

http://www.ncbi.nlm.nih.gov/pubmed/3352601?dopt=Citation

 

Pawson, T., Greer, P., Moran, M., Meckling-Hansen, K., Brooks-Wilson, A. and Sadowski, I. 1987.  Structure-function relationships in cellular and viral fps/fes cytoplasmic protein-tyrosine kinases. In:  J. E. Kudlow, D. H. MacLennan, A. Bernstein, and A. I. Gotlieb, Eds., Biology of Growth Factors: Molecular Biology, Oncogenes, Signal Transduction and Clinical Implications.  Adv. Exp. Med. Biol. Plenum Press, New York and London. Volume 234.

http://www.ncbi.nlm.nih.gov/pubmed/3063089?dopt=Citation

 

1986-1987

Hasel, K., Day, S., Millward, S., Richardson, C., Bellini, W. and Greer, P. 1987. Characterization of cloned measles virus mRNAs by in vitro transcription, translation and immunoprecipitation. Intervirology 28:26-39

http://www.ncbi.nlm.nih.gov/pubmed/3429193?dopt=Citation

 

Greer, P., Hasel, K. and Millward, S.  1986.  Cloning and in vitro expression of the measles virus Matrix Gene. Biochem. Cell Biol. 64:1038-1043

http://www.ncbi.nlm.nih.gov/pubmed/3026420?dopt=Citation

 

Richardson, C.D., Hull, D., Greer, P., Hasel, K., Berkovich, A., Englund, G., Bellini, W., Rima, B. and Lazzarini, R.A.  1986.  The nucleotide sequence of the mRNA encoding the fusion protein of measles virus (Edmonston Strain): A comparison of fusion proteins from several different paramyxoviruses. Virology 155:508-523

http://www.ncbi.nlm.nih.gov/pubmed/3788062?dopt=Citation