Cell Growth Proliferation & Differentiation

Normal development requires the coordination of a wide variety of events that determine the growth, specialization and ultimately, the death of the cell. We are characterizing the underlying molecular mechanisms which control these processes and are determining the relationship between defects in key genes and the etiology of cancer. Regulation at both the level of cytoplasmic signal transduction and nuclear signaling by nuclear receptors, transcription factors, and DNA topoisomerases is being studied. Specific interests include the role of retinoic acid and steroid hormones in development, control of the cell cycle and DNA damage-induced checkpoints, regulation of hematopoiesis, angiogenesis and vasculogenesis, nucleocytoplasmic trafficking of topoisomerase II, liver development and regeneration. This work emphasizes the use of molecular biology in conjunction with a variety of model systems including yeast, zebrafish and transgenic mice as well as cultured cells from a number of species.  See personal pages of individual investigators for more detailed information.

Susan P.C. Cole
Mechanisms of Resistance to Anticancer Drugs and Transport of Chemical Toxicants 

Scott K. Davey
Cell Cycle Checkpoint Control and DNA Repair 

Roger G. Deeley
Gene Expression/Drug Resistance

Peter A. Greer
Transgenic Mouse Models of Proto-oncogene Function

David P. LeBrun
Mechanistic and Correlative Research in Leukemia and Lymphoma

Christopher R. Mueller
Transcription Factors in Growth and Development

Lois M. Mulligan
Role of the RET Proto-oncogene in Neoplastic Growth

Christopher J. Nicol
Involvement of PPAR(gamma) in Breast and Colon Cancer

P. Martin Petkovich
Retinoic Acid Receptors in Development and Differentiation