Full Professor and Director of the Cancer and Genetic Diseases Division Montreal Clinical Research Institute (IRCM)
Thursday, 22 June 2017 at 4:00 pm in QCRI Conference Rooms 100/01
“UNRAVELLING THE COMPLEXITY OF METASTASIS”: Characterizing the roles of the receptor tyrosine kinase AXL in metastatic progression
The majority of breast cancer deaths occur as a result of the formation of metastases. The metastatic process is complex: cancer cells must acquire invasive properties to migrate through the blood vessels to ultimately reach and survive at secondary sites. The expression of AXL correlates with the formation of metastases in several types of cancers, but the mechanism by which AXL plays its pro-metastatic function is poorly understood. We used proteomics approaches (phospho-MS and BioID screens) to identify signalling networks controlled by AXL. We also used in vivo approaches using mouse models and human Patient-Derived Xenografts to determine the involvement of this RTK at multiple stages of the metastatic process. Our results suggest that inhibition of AXL would be beneficial in limiting the spread of breast cancer.