Thursday 31 January 2019 at 4:00 pm in QCRI 100/01 Conf Rms.
Julian Lum, PhD Senior Scientist, Deeley Research Centre, BC Cancer Agency Associate Professor, University of Victoria
"Metabolic Portraits of Tumor Infiltrating Lymphocytes"
The recent success of cellular immunotherapy (e.g. adoptive T cell therapy and CAR-T cell) for treating hematological malignancies has energized the field to replicate this in epithelial cancers. The lack of clinical responses in solid tumors is poorly understand though metabolic competition between tumors and tumor infiltrating lymphocytes has emerged as an key driver for immune suppression. Using mass spectrometry-based analysis, we are comparing the metabolic profile of human ovarian tumor and T cell samples derived from a matched donor specimen. Our results have uncovered distinct metabolic portraits that can serve as targets to enhance T cell-based therapies.
Bio: Dr. Lum is a Senior Scientist at BC Cancer, and Associate Professor at the University of Victoria. He completed his PhD at the University of Ottawa and moved to the University of Pennsylvania for his post-doc studies where he contributed seminal findings to the field of autophagy regulation. He returned to Canada and established his laboratory in Victoria where he has continued his long-standing interest in how cells adapt to metabolic stress and how this could inform new strategies to enhance T cell immunotherapy. Dr. Lum’s group is involved in translational and clinical research in ovarian and prostate cancer, where he has applied his basic research discoveries to launch clinical trials in these disease sites.