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QCRI FCR Seminar (Dr. Sirin Adham)

  • Event Start: Aug 17, 2017 4:00 pm
    Location: QCRI 100/01 Conf Rms

    Dr. Sirin Adham (Sultan Qaboos University, Muscat, Oman)

    Thursday 17 Aug/17 at 4:00 pm in QCRI Conf Rms 100/10

    "Investigating Specific Molecular Targets for Triple Negative Breast Cancer in Clinical Samples"

    Circulating plasma and peripheral blood mononuclear (PBMCs) cells provide an informative snapshot of the systemic physiological state. The role of Neuropilin-1 (NRP-1) and its interacting molecules in breast cancer was associated with progression. We found that circulating and tumor tissue expression of NRP-1 and circulating placental growth factor (PlGF) were upregulated in triple negative breast cancer (TNBC) compared to other subtypes. In PBMCs VEGFR3 and PLXNA1 expression can differentiate between TNBC and non-TNBC tumor subtypes. This work supports the importance of NRP-1-associated molecules in circulation to characterize poor prognosis breast cancer and emphasizes on their role as favorable drug targets.

     

    Host: Dr. Peter Greer greerp@queensu.ca

     

    Everyone is welcome!