QCRI FCR Seminar (Dr. Tricia Cottrell)
Event Start: Oct 15, 2018 4:00 pm
Location: QCRI Conf. Rms. 100/01
a Frontiers of Cancer Research presentation!
Monday 15 October 2018 at 4:00 pm in QCRI 100/01 Conf Rms.
Tricia Cottrell, MD, PhD
Chief Resident, Anatomic Pathology (PGY4)
Johns Hopkins University School of Medicine (Baltimore, MD)
"Histopathologic features of response and resistance to neoadjuvant anti-PD-1 in non-small cell lung carcinoma (NSCLC)"
Features of the pretreatment tumor microenvironment (TME) are broadly associated with patient prognosis and useful in enriching for subsets of patients likely to respond to immune checkpoint blockade. In the neoadjuvant setting, the post-treatment TME provides an early indicator of a particular patient’s response status and allows investigation of mechanisms underlying primary resistance. We systematically identified the histopathologic features of immune-mediate tumor regression following neoadjuvant anti-PD1 in NSCLC. These features were used to develop a reproducible method for quantifying pathologic response in this setting, known as 'Immune-Related Pathologic Response Criteria' (irPRC). Early data suggests that these criteria may also be useful in other tumor types, possibly representing a pan-cancer tool for pathologic response assessment. Finally, we are using an optimized and validated multiplex immunofluorescence protocol to explore both pretreatment and post treatment tumor specimens to improve predictions of therapeutic response and identify mechanisms of resistance to immune checkpoint blockade.
Host: Dr. David M. Berman
Everyone is welcome!